Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline American Airlines

The cheapest airline(s) flying from Des Moines to San Diego is American Airlines.

  • American Airlines American Airlines
  • United Airlines United Airlines
  • Alaska Airlines Alaska Airlines
  • Southwest Airlines Southwest Airlines
Cheapest Month April

Travel Period: January 2025 - December 2025

The cheapest month(s) to fly from Des Moines to San Diego is April.

  • Jan 2025
  • Feb 2025
  • Mar 2025
  • Apr 2025
  • May 2025
  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
  • Oct 2025
  • Nov 2025
  • Dec 2025
Cheapest Day of the Week Tuesday

The cheapest day(s) of the week to fly from Des Moines to San Diego is Tuesday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Sat, 2 Nov, 2024

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      • 17:30 DSM
        20:35 SAN
        5Hrs, 05m Direct
      • DSMDes Moines Airport 17:30 - SAN 20:35 5h 05m Direct
      • DSMDes Moines Airport 17:30
      • SANSan Diego International Airport 20:35
      • 5h 05m
      • Direct
      • Southwest Airlines (WN 3653)Boeing 737 700
      • Southwest Airlines (WN 3653)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • Boeing 737 700
      • 18:15 DSM
        21:43 SAN
        5Hrs, 28m 1 Stop (PHX)
      • DSMDes Moines Airport 18:15 - SAN 21:43 5h 28m 1 Stop (PHX) Phoenix
      • DSMDes Moines Airport 18:15
        PHXPhoenix Sky Harbor Intl Airport 21:27
      • PHXPhoenix Sky Harbor Intl Airport 20:22
        SANSan Diego International Airport 21:43
      • 5h 28m (1h 05m)
      • 1 Stop PHX · Phoenix 1h 05m
      • American Airlines (AA 2158)Airbus
        American Airlines (AA 559)Airbus
      • American Airlines (AA 2158)
        • M
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        • -
        • -
        • S
        • S
      • 18:15 DSM
        00:06 SAN
        7Hrs, 51m 1 Stop (PHX)
      • DSMDes Moines Airport 18:15 - SAN 00:06 7h 51m 1 Stop (PHX) Phoenix
      • DSMDes Moines Airport 18:15
        PHXPhoenix Sky Harbor Intl Airport 23:50
      • PHXPhoenix Sky Harbor Intl Airport 20:22
        SANSan Diego International Airport 00:06
      • 7h 51m (3h 28m)
      • 1 Stop PHX · Phoenix 3h 28m
      • American Airlines (AA 2158)Airbus
        American Airlines (AA 2983)Airbus
      • American Airlines (AA 2158)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 18:25 DSM
        22:05 SAN
        5Hrs, 40m 1 Stop (STL)
      • DSMDes Moines Airport 18:25 - SAN 22:05 5h 40m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 18:25
        STLSt Louis Lambert Intl Airport 20:05
      • STLSt Louis Lambert Intl Airport 19:30
        SANSan Diego International Airport 22:05
      • 5h 40m (35m)
      • 1 Stop STL · Saint Louis 35m
      • Southwest Airlines (WN 2925)Boeing 737 700
        Southwest Airlines (WN 4198)Boeing 737 700
      • Southwest Airlines (WN 2925)
        • M
        • -
        • -
        • -
        • -
        • -
        • -
      • 18:45 DSM
        22:55 SAN
        6Hrs, 10m 1 Stop (STL)
      • DSMDes Moines Airport 18:45 - SAN 22:55 6h 10m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 18:45
        STLSt Louis Lambert Intl Airport 20:55
      • STLSt Louis Lambert Intl Airport 19:50
        SANSan Diego International Airport 22:55
      • 6h 10m (1h 05m)
      • 1 Stop STL · Saint Louis 1h 05m
      • Southwest Airlines (WN 372)Boeing 737 Max 8 Passenger
        Southwest Airlines (WN 2098)Boeing 737 700
      • Southwest Airlines (WN 372)
        • -
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        • -
        • -
        • -
        • -
      • 19:06 DSM
        23:56 SAN
        6Hrs, 50m 1 Stop (DEN)
      • DSMDes Moines Airport 19:06 - SAN 23:56 6h 50m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 19:06
        DENDenver Intl Airport 22:30
      • DENDenver Intl Airport 20:12
        SANSan Diego International Airport 23:56
      • 6h 50m (2h 18m)
      • 1 Stop DEN · Denver 2h 18m
      • Frontier Airlines (F9 1677)Airbus A320 Neo
        Frontier Airlines (F9 4927)Airbus
      • Frontier Airlines (F9 1677)
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        • -
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        • -
        • -
      • 19:06 DSM
        23:56 SAN
        6Hrs, 50m 1 Stop (DEN)
      • DSMDes Moines Airport 19:06 - SAN 23:56 6h 50m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 19:06
        DENDenver Intl Airport 22:30
      • DENDenver Intl Airport 20:12
        SANSan Diego International Airport 23:56
      • 6h 50m (2h 18m)
      • 1 Stop DEN · Denver 2h 18m
      • Frontier Airlines (F9 1677)Airbus A321 Neo
        Frontier Airlines (F9 4927)Airbus A321 Neo
      • Frontier Airlines (F9 1677)
        • M
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        • -
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        • F
        • -
        • -
      • 19:30 DSM
        23:56 SAN
        6Hrs, 26m 1 Stop (DEN)
      • DSMDes Moines Airport 19:30 - SAN 23:56 6h 26m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 19:30
        DENDenver Intl Airport 22:30
      • DENDenver Intl Airport 20:36
        SANSan Diego International Airport 23:56
      • 6h 26m (1h 54m)
      • 1 Stop DEN · Denver 1h 54m
      • Frontier Airlines (F9 1677)Airbus
        Frontier Airlines (F9 4927)Airbus
      • Frontier Airlines (F9 1677)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 05:00 DSM
        08:52 SAN
        5Hrs, 52m 1 Stop (PHX)
      • DSMDes Moines Airport 05:00 - SAN 08:52 5h 52m 1 Stop (PHX) Phoenix
      • DSMDes Moines Airport 05:00
        PHXPhoenix Sky Harbor Intl Airport 08:34
      • PHXPhoenix Sky Harbor Intl Airport 07:09
        SANSan Diego International Airport 08:52
      • 5h 52m (1h 25m)
      • 1 Stop PHX · Phoenix 1h 25m
      • American Airlines (AA 1795)Airbus
        American Airlines (AA 1949)Airbus
      • American Airlines (AA 1795)
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        • F
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        • S
      • 05:00 DSM
        10:08 SAN
        7Hrs, 08m 1 Stop (DFW)
      • DSMDes Moines Airport 05:00 - SAN 10:08 7h 08m 1 Stop (DFW) Dallas
      • DSMDes Moines Airport 05:00
        DFWDallas/Fort Worth Intl Airport 08:50
      • DFWDallas/Fort Worth Intl Airport 07:09
        SANSan Diego International Airport 10:08
      • 7h 08m (1h 41m)
      • 1 Stop DFW · Dallas 1h 41m
      • American Airlines (AA 2326)Airbus
        American Airlines (AA 384)Airbus
      • American Airlines (AA 2326)
        • M
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        • -
        • -
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        • S
      • 05:00 DSM
        10:09 SAN
        7Hrs, 09m 1 Stop (DFW)
      • DSMDes Moines Airport 05:00 - SAN 10:09 7h 09m 1 Stop (DFW) Dallas
      • DSMDes Moines Airport 05:00
        DFWDallas/Fort Worth Intl Airport 08:50
      • DFWDallas/Fort Worth Intl Airport 07:09
        SANSan Diego International Airport 10:09
      • 7h 09m (1h 41m)
      • 1 Stop DFW · Dallas 1h 41m
      • American Airlines (AA 2326)Airbus
        American Airlines (AA 384)Airbus
      • American Airlines (AA 2326)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 05:00 DSM
        10:09 SAN
        7Hrs, 09m 1 Stop (DFW)
      • DSMDes Moines Airport 05:00 - SAN 10:09 7h 09m 1 Stop (DFW) Dallas
      • DSMDes Moines Airport 05:00
        DFWDallas/Fort Worth Intl Airport 08:50
      • DFWDallas/Fort Worth Intl Airport 07:09
        SANSan Diego International Airport 10:09
      • 7h 09m (1h 41m)
      • 1 Stop DFW · Dallas 1h 41m
      • American Airlines (AA 2326)Airbus
        American Airlines (AA 384)Boeing 737 800
      • American Airlines (AA 2326)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 05:00 DSM
        11:35 SAN
        8Hrs, 35m 1 Stop (PHX)
      • DSMDes Moines Airport 05:00 - SAN 11:35 8h 35m 1 Stop (PHX) Phoenix
      • DSMDes Moines Airport 05:00
        PHXPhoenix Sky Harbor Intl Airport 11:11
      • PHXPhoenix Sky Harbor Intl Airport 07:09
        SANSan Diego International Airport 11:35
      • 8h 35m (4h 02m)
      • 1 Stop PHX · Phoenix 4h 02m
      • American Airlines (AA 1795)Airbus
        American Airlines (AA 3105)Airbus
      • American Airlines (AA 1795)
        • M
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        • -
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        • S
      • 05:10 DSM
        09:20 SAN
        6Hrs, 10m 1 Stop (STL)
      • DSMDes Moines Airport 05:10 - SAN 09:20 6h 10m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 05:10
        STLSt Louis Lambert Intl Airport 07:15
      • STLSt Louis Lambert Intl Airport 06:30
        SANSan Diego International Airport 09:20
      • 6h 10m (45m)
      • 1 Stop STL · Saint Louis 45m
      • Southwest Airlines (WN 372)Boeing 737 700
        Southwest Airlines (WN 4178)Boeing 737 700
      • Southwest Airlines (WN 372)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 05:20 DSM
        12:33 SAN
        9Hrs, 13m 1 Stop (ORD)
      • DSMDes Moines Airport 05:20 - SAN 12:33 9h 13m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 05:20
        ORDChicago O'Hare International Airport 10:05
      • ORDChicago O'Hare International Airport 06:52
        SANSan Diego International Airport 12:33
      • 9h 13m (3h 13m)
      • 1 Stop ORD · Chicago 3h 13m
      • American Airlines (AA 6389)Crj 700 Canadair Regional
        American Airlines (AA 2131)Boeing 737 800
      • American Airlines (AA 6389)
        • M
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        • -
        • -
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        • S
      • 05:30 DSM
        08:52 SAN
        5Hrs, 22m 1 Stop (PHX)
      • DSMDes Moines Airport 05:30 - SAN 08:52 5h 22m 1 Stop (PHX) Phoenix
      • DSMDes Moines Airport 05:30
        PHXPhoenix Sky Harbor Intl Airport 08:34
      • PHXPhoenix Sky Harbor Intl Airport 07:39
        SANSan Diego International Airport 08:52
      • 5h 22m (55m)
      • 1 Stop PHX · Phoenix 55m
      • American Airlines (AA 1795)Airbus
        American Airlines (AA 1949)Airbus
      • American Airlines (AA 1795)
        • -
        • -
        • -
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        • -
        • -
        • -
      • 10:16 FAT
        07:39 PHX
        8Hrs, 01m 1 Stop (SAN)
      • FATFresno Yosemite International Airport 10:16 - PHX 07:39 8h 01m 1 Stop (SAN) San Diego
      • FATFresno Yosemite International Airport 10:16
        DSMDes Moines Airport 05:30
      • SANSan Diego International Airport 11:31
        PHXPhoenix Sky Harbor Intl Airport 07:39
      • 8h 01m (1h 43m)
      • 1 Stop SAN · San Diego 1h 43m
      • Alaska Airlines (AS 3331)Embraer Emb 175
        American Airlines (AA 1795)Airbus
      • Alaska Airlines (AS 3331)
        • -
        • -
        • -
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      • 05:30 DSM
        11:35 SAN
        8Hrs, 05m 1 Stop (PHX)
      • DSMDes Moines Airport 05:30 - SAN 11:35 8h 05m 1 Stop (PHX) Phoenix
      • DSMDes Moines Airport 05:30
        PHXPhoenix Sky Harbor Intl Airport 11:11
      • PHXPhoenix Sky Harbor Intl Airport 07:39
        SANSan Diego International Airport 11:35
      • 8h 05m (3h 32m)
      • 1 Stop PHX · Phoenix 3h 32m
      • American Airlines (AA 1795)Airbus
        American Airlines (AA 3105)Airbus
      • American Airlines (AA 1795)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 05:30 DSM
        11:55 SAN
        8Hrs, 25m 1 Stop (STL)
      • DSMDes Moines Airport 05:30 - SAN 11:55 8h 25m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 05:30
        STLSt Louis Lambert Intl Airport 09:50
      • STLSt Louis Lambert Intl Airport 06:50
        SANSan Diego International Airport 11:55
      • 8h 25m (3h)
      • 1 Stop STL · Saint Louis 3h
      • Southwest Airlines (WN 372)Boeing 737 700
        Southwest Airlines (WN 4339)Boeing 737 Max 8 Passenger
      • Southwest Airlines (WN 372)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 05:40 DSM
        11:55 SAN
        8Hrs, 15m 1 Stop (STL)
      • DSMDes Moines Airport 05:40 - SAN 11:55 8h 15m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 05:40
        STLSt Louis Lambert Intl Airport 09:50
      • STLSt Louis Lambert Intl Airport 07:00
        SANSan Diego International Airport 11:55
      • 8h 15m (2h 50m)
      • 1 Stop STL · Saint Louis 2h 50m
      • Southwest Airlines (WN 372)Boeing 737 700
        Southwest Airlines (WN 3010)Boeing 737 700
      • Southwest Airlines (WN 372)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 05:50 DSM
        12:00 SAN
        8Hrs, 10m 1 Stop (STL)
      • DSMDes Moines Airport 05:50 - SAN 12:00 8h 10m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 05:50
        STLSt Louis Lambert Intl Airport 09:55
      • STLSt Louis Lambert Intl Airport 07:10
        SANSan Diego International Airport 12:00
      • 8h 10m (2h 45m)
      • 1 Stop STL · Saint Louis 2h 45m
      • Southwest Airlines (WN 372)Boeing 737 700
        Southwest Airlines (WN 4499)Boeing 737 700
      • Southwest Airlines (WN 372)
        • M
        • -
        • -
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        • -
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      • 06:00 DSM
        09:33 SAN
        5Hrs, 33m 1 Stop (DEN)
      • DSMDes Moines Airport 06:00 - SAN 09:33 5h 33m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:00
        DENDenver Intl Airport 08:05
      • DENDenver Intl Airport 07:04
        SANSan Diego International Airport 09:33
      • 5h 33m (1h 01m)
      • 1 Stop DEN · Denver 1h 01m
      • United Airlines (UA 497)Airbus
        United Airlines (UA 2309)Boeing 737 800
      • United Airlines (UA 497)
        • M
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        • -
        • -
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        • -
      • 06:00 DSM
        09:33 SAN
        5Hrs, 33m 1 Stop (DEN)
      • DSMDes Moines Airport 06:00 - SAN 09:33 5h 33m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:00
        DENDenver Intl Airport 08:05
      • DENDenver Intl Airport 07:04
        SANSan Diego International Airport 09:33
      • 5h 33m (1h 01m)
      • 1 Stop DEN · Denver 1h 01m
      • United Airlines (UA 497)Boeing 737 800
        United Airlines (UA 2309)Boeing 737 800
      • United Airlines (UA 497)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 06:00 DSM
        09:33 SAN
        5Hrs, 33m 1 Stop (DEN)
      • DSMDes Moines Airport 06:00 - SAN 09:33 5h 33m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:00
        DENDenver Intl Airport 08:05
      • DENDenver Intl Airport 07:04
        SANSan Diego International Airport 09:33
      • 5h 33m (1h 01m)
      • 1 Stop DEN · Denver 1h 01m
      • United Airlines (UA 497)Airbus
        United Airlines (UA 2309)Boeing 737 Max 8 Passenger
      • United Airlines (UA 497)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 06:00 DSM
        11:48 SAN
        7Hrs, 48m 1 Stop (DEN)
      • DSMDes Moines Airport 06:00 - SAN 11:48 7h 48m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:00
        DENDenver Intl Airport 10:20
      • DENDenver Intl Airport 07:04
        SANSan Diego International Airport 11:48
      • 7h 48m (3h 16m)
      • 1 Stop DEN · Denver 3h 16m
      • United Airlines (UA 497)Airbus
        United Airlines (UA 1842)Boeing 737 800
      • United Airlines (UA 497)
        • M
        • T
        • W
        • -
        • -
        • -
        • -
      • 06:00 DSM
        11:48 SAN
        7Hrs, 48m 1 Stop (DEN)
      • DSMDes Moines Airport 06:00 - SAN 11:48 7h 48m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:00
        DENDenver Intl Airport 10:20
      • DENDenver Intl Airport 07:04
        SANSan Diego International Airport 11:48
      • 7h 48m (3h 16m)
      • 1 Stop DEN · Denver 3h 16m
      • United Airlines (UA 497)Boeing 737 800
        United Airlines (UA 1842)Boeing 737 800
      • United Airlines (UA 497)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 06:00 DSM
        13:08 SAN
        9Hrs, 08m 1 Stop (DEN)
      • DSMDes Moines Airport 06:00 - SAN 13:08 9h 08m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:00
        DENDenver Intl Airport 11:40
      • DENDenver Intl Airport 07:04
        SANSan Diego International Airport 13:08
      • 9h 08m (4h 36m)
      • 1 Stop DEN · Denver 4h 36m
      • United Airlines (UA 497)Airbus
        United Airlines (UA 2381)Boeing 737 Max 8 Passenger
      • United Airlines (UA 497)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 06:30 DSM
        10:05 SAN
        5Hrs, 35m 1 Stop (DEN)
      • DSMDes Moines Airport 06:30 - SAN 10:05 5h 35m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:30
        DENDenver Intl Airport 08:40
      • DENDenver Intl Airport 07:30
        SANSan Diego International Airport 10:05
      • 5h 35m (1h 10m)
      • 1 Stop DEN · Denver 1h 10m
      • Southwest Airlines (WN 1784)Boeing 737 700
        Southwest Airlines (WN 6481)Boeing 737 700
      • Southwest Airlines (WN 1784)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 06:30 DSM
        10:45 SAN
        6Hrs, 15m 1 Stop (DEN)
      • DSMDes Moines Airport 06:30 - SAN 10:45 6h 15m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:30
        DENDenver Intl Airport 09:20
      • DENDenver Intl Airport 07:30
        SANSan Diego International Airport 10:45
      • 6h 15m (1h 50m)
      • 1 Stop DEN · Denver 1h 50m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 1535)Boeing 737 Max 8 Passenger
      • Southwest Airlines (WN 845)
        • -
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        • W
        • -
        • -
        • -
        • -
      • 06:30 DSM
        11:30 SAN
        7Hrs, 00m 1 Stop (DEN)
      • DSMDes Moines Airport 06:30 - SAN 11:30 7h 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:30
        DENDenver Intl Airport 10:00
      • DENDenver Intl Airport 07:30
        SANSan Diego International Airport 11:30
      • 7h (2h 30m)
      • 1 Stop DEN · Denver 2h 30m
      • Southwest Airlines (WN 1784)Boeing 737 700
        Southwest Airlines (WN 1987)Boeing 737 700
      • Southwest Airlines (WN 1784)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 06:30 DSM
        12:10 SAN
        7Hrs, 40m 1 Stop (DEN)
      • DSMDes Moines Airport 06:30 - SAN 12:10 7h 40m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:30
        DENDenver Intl Airport 10:45
      • DENDenver Intl Airport 07:30
        SANSan Diego International Airport 12:10
      • 7h 40m (3h 15m)
      • 1 Stop DEN · Denver 3h 15m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 1087)Boeing 737 700
      • Southwest Airlines (WN 845)
        • -
        • T
        • W
        • -
        • -
        • -
        • -
      • 06:35 DSM
        10:45 SAN
        6Hrs, 10m 1 Stop (DEN)
      • DSMDes Moines Airport 06:35 - SAN 10:45 6h 10m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:35
        DENDenver Intl Airport 09:20
      • DENDenver Intl Airport 07:35
        SANSan Diego International Airport 10:45
      • 6h 10m (1h 45m)
      • 1 Stop DEN · Denver 1h 45m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 5254)Boeing 737 800
      • Southwest Airlines (WN 845)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 11:05 BOI
        07:35 DEN
        7Hrs, 45m 1 Stop (SAN)
      • BOIBoise Airport 11:05 - DEN 07:35 7h 45m 1 Stop (SAN) San Diego
      • BOIBoise Airport 11:05
        DSMDes Moines Airport 06:35
      • SANSan Diego International Airport 12:20
        DENDenver Intl Airport 07:35
      • 7h 45m (1h 30m)
      • 1 Stop SAN · San Diego 1h 30m
      • Southwest Airlines (WN 2634)Boeing 737 800
        Southwest Airlines (WN 845)Boeing 737 700
      • Southwest Airlines (WN 2634)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 06:40 DSM
        10:05 SAN
        5Hrs, 25m 1 Stop (DEN)
      • DSMDes Moines Airport 06:40 - SAN 10:05 5h 25m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:40
        DENDenver Intl Airport 08:35
      • DENDenver Intl Airport 07:45
        SANSan Diego International Airport 10:05
      • 5h 25m (50m)
      • 1 Stop DEN · Denver 50m
      • Southwest Airlines (WN 1170)Boeing 737 700
        Southwest Airlines (WN 875)Boeing 737 700
      • Southwest Airlines (WN 1170)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 06:40 DSM
        12:05 SAN
        7Hrs, 25m 1 Stop (DEN)
      • DSMDes Moines Airport 06:40 - SAN 12:05 7h 25m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 06:40
        DENDenver Intl Airport 10:40
      • DENDenver Intl Airport 07:45
        SANSan Diego International Airport 12:05
      • 7h 25m (2h 55m)
      • 1 Stop DEN · Denver 2h 55m
      • Southwest Airlines (WN 1170)Boeing 737 700
        Southwest Airlines (WN 2730)Boeing 737 700
      • Southwest Airlines (WN 1170)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 11:15 ABQ
        07:45 DEN
        7Hrs, 35m 1 Stop (SAN)
      • ABQAlbuquerque Airport 11:15 - DEN 07:45 7h 35m 1 Stop (SAN) San Diego
      • ABQAlbuquerque Airport 11:15
        DSMDes Moines Airport 06:40
      • SANSan Diego International Airport 12:15
        DENDenver Intl Airport 07:45
      • 7h 35m (2h 10m)
      • 1 Stop SAN · San Diego 2h 10m
      • Southwest Airlines (WN 1199)Boeing 737 700
        Southwest Airlines (WN 1170)Boeing 737 700
      • Southwest Airlines (WN 1199)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 12:05 PHX
        07:45 DEN
        7Hrs, 40m 1 Stop (SAN)
      • PHXPhoenix Sky Harbor Intl Airport 12:05 - DEN 07:45 7h 40m 1 Stop (SAN) San Diego
      • PHXPhoenix Sky Harbor Intl Airport 12:05
        DSMDes Moines Airport 06:40
      • SANSan Diego International Airport 12:20
        DENDenver Intl Airport 07:45
      • 7h 40m (2h 20m)
      • 1 Stop SAN · San Diego 2h 20m
      • Southwest Airlines (WN 1650)Boeing 737 Max 8 Passenger
        Southwest Airlines (WN 1170)Boeing 737 700
      • Southwest Airlines (WN 1650)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 06:50 DSM
        13:00 SAN
        8Hrs, 10m 1 Stop (STL)
      • DSMDes Moines Airport 06:50 - SAN 13:00 8h 10m 1 Stop (STL) Saint Louis
      • DSMDes Moines Airport 06:50
        STLSt Louis Lambert Intl Airport 11:00
      • STLSt Louis Lambert Intl Airport 08:05
        SANSan Diego International Airport 13:00
      • 8h 10m (2h 55m)
      • 1 Stop STL · Saint Louis 2h 55m
      • Southwest Airlines (WN 372)Boeing 737 700
        Southwest Airlines (WN 3648)Boeing 737 Max 8 Passenger
      • Southwest Airlines (WN 372)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 06:55 DSM
        13:49 SAN
        8Hrs, 54m 1 Stop (CLT)
      • DSMDes Moines Airport 06:55 - SAN 13:49 8h 54m 1 Stop (CLT) Charlotte
      • DSMDes Moines Airport 06:55
        CLTCharlotte Airport 11:21
      • CLTCharlotte Airport 10:12
        SANSan Diego International Airport 13:49
      • 8h 54m (1h 09m)
      • 1 Stop CLT · Charlotte 1h 09m
      • American Airlines (AA 2854)Airbus
        American Airlines (AA 466)Airbus
      • American Airlines (AA 2854)
        • M
        • T
        • W
        • -
        • F
        • S
        • S
      • 07:00 DSM
        11:10 SAN
        6Hrs, 10m 1 Stop (DEN)
      • DSMDes Moines Airport 07:00 - SAN 11:10 6h 10m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 07:00
        DENDenver Intl Airport 09:45
      • DENDenver Intl Airport 08:05
        SANSan Diego International Airport 11:10
      • 6h 10m (1h 40m)
      • 1 Stop DEN · Denver 1h 40m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 3547)Boeing 737 Max 8 Passenger
      • Southwest Airlines (WN 845)
        • M
        • -
        • -
        • -
        • -
        • -
        • -
      • 07:00 DSM
        13:10 SAN
        8Hrs, 10m 1 Stop (DEN)
      • DSMDes Moines Airport 07:00 - SAN 13:10 8h 10m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 07:00
        DENDenver Intl Airport 11:45
      • DENDenver Intl Airport 08:05
        SANSan Diego International Airport 13:10
      • 8h 10m (3h 40m)
      • 1 Stop DEN · Denver 3h 40m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 3097)Boeing 737 Max 8 Passenger
      • Southwest Airlines (WN 845)
        • M
        • -
        • -
        • -
        • -
        • -
        • -
      • 08:00 DSM
        13:50 SAN
        7Hrs, 50m 1 Stop (IAH)
      • DSMDes Moines Airport 08:00 - SAN 13:50 7h 50m 1 Stop (IAH) Houston
      • DSMDes Moines Airport 08:00
        IAHHouston George Bush Intercontinental Airport 12:20
      • IAHHouston George Bush Intercontinental Airport 10:40
        SANSan Diego International Airport 13:50
      • 7h 50m (1h 40m)
      • 1 Stop IAH · Houston 1h 40m
      • United Airlines (UA 5456)Embraer 175
        United Airlines (UA 2486)Boeing 737 900
      • United Airlines (UA 5456)
        • M
        • -
        • W
        • -
        • -
        • -
        • S
      • 08:00 DSM
        13:50 SAN
        7Hrs, 50m 1 Stop (IAH)
      • DSMDes Moines Airport 08:00 - SAN 13:50 7h 50m 1 Stop (IAH) Houston
      • DSMDes Moines Airport 08:00
        IAHHouston George Bush Intercontinental Airport 12:20
      • IAHHouston George Bush Intercontinental Airport 10:40
        SANSan Diego International Airport 13:50
      • 7h 50m (1h 40m)
      • 1 Stop IAH · Houston 1h 40m
      • United Airlines (UA 6309)Embraer 175
        United Airlines (UA 2486)Boeing 737 900
      • United Airlines (UA 6309)
        • -
        • -
        • -
        • -
        • F
        • S
        • -
      • 08:00 DSM
        13:50 SAN
        7Hrs, 50m 1 Stop (IAH)
      • DSMDes Moines Airport 08:00 - SAN 13:50 7h 50m 1 Stop (IAH) Houston
      • DSMDes Moines Airport 08:00
        IAHHouston George Bush Intercontinental Airport 12:20
      • IAHHouston George Bush Intercontinental Airport 10:40
        SANSan Diego International Airport 13:50
      • 7h 50m (1h 40m)
      • 1 Stop IAH · Houston 1h 40m
      • United Airlines (UA 5456)Embraer 175
        United Airlines (UA 2486)Boeing 737 800
      • United Airlines (UA 5456)
        • -
        • -
        • -
        • T
        • -
        • -
        • -
      • 08:00 DSM
        15:32 SAN
        9Hrs, 32m 1 Stop (ORD)
      • DSMDes Moines Airport 08:00 - SAN 15:32 9h 32m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 08:00
        ORDChicago O'Hare International Airport 13:02
      • ORDChicago O'Hare International Airport 09:27
        SANSan Diego International Airport 15:32
      • 9h 32m (3h 35m)
      • 1 Stop ORD · Chicago 3h 35m
      • United Airlines (UA 1363)Boeing 737 800
        United Airlines (UA 2683)Boeing 737 800
      • United Airlines (UA 1363)
        • -
        • -
        • W
        • -
        • F
        • S
        • S
      • 08:00 DSM
        15:32 SAN
        9Hrs, 32m 1 Stop (ORD)
      • DSMDes Moines Airport 08:00 - SAN 15:32 9h 32m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 08:00
        ORDChicago O'Hare International Airport 13:02
      • ORDChicago O'Hare International Airport 09:27
        SANSan Diego International Airport 15:32
      • 9h 32m (3h 35m)
      • 1 Stop ORD · Chicago 3h 35m
      • United Airlines (UA 1363)Boeing 737 800
        United Airlines (UA 2683)Boeing 737 900
      • United Airlines (UA 1363)
        • -
        • T
        • -
        • -
        • -
        • -
        • -
      • 08:00 DSM
        15:32 SAN
        9Hrs, 32m 1 Stop (ORD)
      • DSMDes Moines Airport 08:00 - SAN 15:32 9h 32m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 08:00
        ORDChicago O'Hare International Airport 13:02
      • ORDChicago O'Hare International Airport 09:27
        SANSan Diego International Airport 15:32
      • 9h 32m (3h 35m)
      • 1 Stop ORD · Chicago 3h 35m
      • United Airlines (UA 1363)Boeing 737 800
        United Airlines (UA 2683)Boeing 737 Max 8 Passenger
      • United Airlines (UA 1363)
        • M
        • -
        • -
        • -
        • -
        • -
        • -
      • 08:45 DSM
        12:50 SAN
        6Hrs, 05m 1 Stop (DEN)
      • DSMDes Moines Airport 08:45 - SAN 12:50 6h 05m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 08:45
        DENDenver Intl Airport 11:25
      • DENDenver Intl Airport 09:50
        SANSan Diego International Airport 12:50
      • 6h 05m (1h 35m)
      • 1 Stop DEN · Denver 1h 35m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 2038)Boeing 737 700
      • Southwest Airlines (WN 845)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 13:50 PHX
        09:50 DEN
        7Hrs, 20m 1 Stop (SAN)
      • PHXPhoenix Sky Harbor Intl Airport 13:50 - DEN 09:50 7h 20m 1 Stop (SAN) San Diego
      • PHXPhoenix Sky Harbor Intl Airport 13:50
        DSMDes Moines Airport 08:45
      • SANSan Diego International Airport 14:05
        DENDenver Intl Airport 09:50
      • 7h 20m (2h)
      • 1 Stop SAN · San Diego 2h
      • Southwest Airlines (WN 2777)Boeing 737 700
        Southwest Airlines (WN 845)Boeing 737 700
      • Southwest Airlines (WN 2777)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 08:45 DSM
        14:35 SAN
        7Hrs, 50m 1 Stop (DEN)
      • DSMDes Moines Airport 08:45 - SAN 14:35 7h 50m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 08:45
        DENDenver Intl Airport 13:10
      • DENDenver Intl Airport 09:50
        SANSan Diego International Airport 14:35
      • 7h 50m (3h 20m)
      • 1 Stop DEN · Denver 3h 20m
      • Southwest Airlines (WN 845)Boeing 737 700
        Southwest Airlines (WN 2807)Boeing 737 700
      • Southwest Airlines (WN 845)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 08:50 DSM
        13:08 SAN
        6Hrs, 18m 1 Stop (DEN)
      • DSMDes Moines Airport 08:50 - SAN 13:08 6h 18m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 08:50
        DENDenver Intl Airport 11:40
      • DENDenver Intl Airport 10:05
        SANSan Diego International Airport 13:08
      • 6h 18m (1h 35m)
      • 1 Stop DEN · Denver 1h 35m
      • United Airlines (UA 581)Airbus
        United Airlines (UA 2381)Boeing 737 Max 8 Passenger
      • United Airlines (UA 581)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
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      What’s the fastest flight time from Des Moines to San Diego?

      The fastest flight time for direct flights from Des Moines to San Diego is 5 hours 5 minutes. Check latest flight schedules & prices on Wego.

      How far is San Diego from Des Moines?

      The flight distance between Des Moines and San Diego is 2299km. Check all available flights on Wego.

      When is the earliest and latest flight of the day?

      The earliest flight of the day departs at 05:00. The last flight of the day departs at 18:15. See the full list of flight times on Wego.

      How many airlines offer direct flights from Des Moines to San Diego?

      There are 1 airlines that offer direct flights from Des Moines to San Diego. Find out the list of airlines on Wego.

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      Des Moines Airport DSM

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